論文 - 永井　宏史

Comparison of cytotoxicity among pectenotoxin-2 and other oxidized pectenotoxins in a rat myoblast cell line (L6) and a human rhabdomyosarcoma cell line (RD).

Ryoji Matsushima, Saori Kikutsugi, Ryuichi Watanabe, Hajime Uchida, Takeshi Yasumoto, Hiroshi Nagai, Masaki Kaneniwa, Toshiyuki Suzuki , 2015年08月

Fundamental Toxicological Sciences , 2 , 49 - 54

Assimilation, accumulation and metabolism of dinophysistoxins (DTXs) and pectenotoxins (PTXs) in the Japanese scallop Patinopecten yessoensis.

Ryoji Matsushim, Hajime Uchida, Satoshi Nagai, Ryuichi Watanabe, Michiya Kamio, Hiroshi Nagai, Masaki Kaneniwa, Toshiyuki Suzuki , 2015年03月

Toxins , 7 , 5141 - 5154

Two New Lyngbyatoxin Derivatives from the Cyanobacterium Moorea producens

Weina Jiang, Satoshi Tan, Yusuke Hanaki, Kazuhiro Irie, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai. , 2014年12月

Marine Drugs , 12 , 5788 - 5800

A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens.

Weina Jiang, Wei Zhou, Hajime Uchida, Masayuki Kikumori, Kazuhiro Irie, Ryuichi Watanabe , Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai , 2014年11月

Marine Drugs , 12 , 2748 - 2748

A convenient HPLC method of okadaic acid analogues as 9-anthrylmethyl esters with an automatic column switching cleanup method.

Hajime Uchida, Ryuichi Watanabe, Ryoji Matsushima, Naoyuki Uchida, Hiroshi Nagai, Michiya Kamio, Takeshi Yasumoto, Toshiyuki Suzuki. , 2014年08月

Journal of AOAC International , 97 , 391 - 397

Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.

Ryo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie , 2013年11月

Bioorganic & Medicinal Chemistry Letters , 23 , 4319 - 4323

Evaluation of the bioactivities of water-soluble extracts from twelve deep-sea jellyfish species.

Takenori Kawabata, Dhugal J. Lindsay, Minoru Kitamura, Satoshi Konishi, Jun Nishikawa, Shuhei Nishida, Michiya Kamio, Hiroshi Nagai. , 2013年11月

Fisheries Science , 79 , 487 - 494

LC-MS/MS analysis of palytoxin analogues in blue humphead parrotfish Scarus ovifrons causing human poisoning in Japan.

Toshiyuki Suzuki, Ryuichi Watanabe, Ryoji Matsushima, Kenji Ishihara, Hajime Uchida, Saori Kikutsugi, Tomoko Harada , Hiroshi Nagai, Masao Adachi, Takeshi Yasumoto, Masakazu Murata , 2013年08月

Food Additives & Contaminants , 30 , 1358 - 1364

クラゲの毒に関する研究の現状

永井宏史 , 2013年03月

日本水産学会誌 , 79 , 104 - 104

Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity. Journal of Medicinal Chemistry

Masayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie , 2012年11月

Journal of Medicinal Chemistry , 55 , 5614 - 5626

LC-MS/MS analysis of novel ovatoxin isomers in several Ostreopsis strains collected in Japan　

Toshiyuki Suzuk, Ryuichi Watanabe, Hajime Uchida, Ryoji Matsushima, Hiroshi Nagai, Takeshi Yasumoto, Takamichi Yoshimatsu, Shinya Sato, Masao Adachi. , 2012年03月

Harmful Algae , 20 , 81 - 91

Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with anti-proliferative activity like bryostatin-1.

K. Irie, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R.C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa. , 2012年03月

Pure Appl. Chem. , 84 , 1341 - 1351

Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin

Y. Nakagawa, M. Kikumori, R.C. Yanagita, A. Murakami, H. Tokuda, H. Nagai, K. Irie , 2011年08月

Biosci. Biotech. Biochem. , 75 , 1167 - 1173

刺胞動物のタンパク質毒素に関する研究

永井宏史 , 2011年08月

日本水産学会誌 , ７７ , 368 - 371

Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.

R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai, K. Irie. , 2010年10月

Bioorganic & Medicinal Chemistry Letters , 20 , 6064 - 6066

Characterization of a new hemolytic protein toxin from the sea anemone Anthopleura asiatica.

Yuuki Kohno, Hiroshi Satoh, Akiko Iguchi and Hiroshi Nagai , 2009年08月

Fisheries Science , 75 , 1049 - 1054

Isolation and cDNA cloning of an antibacterial L-amino acid oxidase from the skin mucus of the great sculpin Myoxochephalus polyacanthocephalus.

Yuji Nagashima, Chihiro Tsukamoto, Yoichiro Kitani, Shoichiro Ishizaki, Hiroshi Nagai and Takashi Yanagimoto , 2009年08月

Comp. Biochem. Physiol. Part B , 154 , 55 - 61

Structual characterizatio of plancitoxin I, a deoxyribonucleases II-like lethal factor from the crown-of-thorns starfich Acanthaster planci, by expression in Chinese hamster ovary cells.

Ai Watanabe, Hiroshi Nagai, Yuji Nagashima and Kazuo Shiomi , 2009年08月

Fisheries Science , 75 , 225 - 331

A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-like activity.

Yu Nakagawa, Ryo C. Yanagita, Naoko Hamada, Akira Murakami, Hideyuki Takahashi, Naoaki Saito, Hiroshi Nagai and Kazuhiro Irie , 2009年08月

Journal of the American Chemical Society , 131 , 7573 - 7579

JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.

T. Fujiwara, J.H. Hwang, A. Kanamoto, H. Nagai, M. Takagi and K. Shin-Ya , 2009年08月

Journal of Antibiotics , 62 , 393 - 395