論文 - 永井 宏史
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Okeaniazole A: Thiazole-containing cyclopeptide from the marine cyanobacterium <i>Okeania hirsuta</i> with antileishmanial activity
Botao Zhang, Ryoya Kawabe, Michiya Kamio, Hajime Uchida, Natsuki Matsuura, Kanami Mori-Yasumoto, Masayuki Satake, Hiroshi Nagai , 2024年10月
Tetrahedron Letters , 150 , 155284 - 155284
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(10<i>E</i>,15<i>Z</i>)-12-(Dimethylsulfonio)-9,13-dihydroxyoctadeca-10,15-dienoate
Haruka Nishino, Bo-Tao Zhang, Hajime Uchida, Michiya Kamio, Hiroshi Nagai, Masayuki Satake , 2024年03月
Molbank , 2024 (1) , M1784 - M1784
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<i>N</i>-Desmethylmajusculamide B, a lipopeptide isolated from the Okinawan cyanobacterium <i>Okeania hirsuta</i>
Bo-Tao Zhang, Haruka Nishino, Ryoya Kawabe, Michiya Kamio, Ryuichi Watanabe, Hajime Uchida, Masayuki Satake, Hiroshi Nagai , 2024年02月
Bioscience, Biotechnology, and Biochemistry
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N-Desmethylmajusculamide B, a lipopeptide isolated from the Okinawan cyanobacterium Okeania hirsuta
ニシノ ハルカ, カワベ リョウヤ, カミオ ミチヤ, 渡邊 龍一, 内田 肇, サタケ マサユキ, ナガイ ヒロシ , 2024年02月
Bioscience, Biotechnology, and Biochemistry , 88 (5) , 517 - 521
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Okeanic acid-A, a trihydroxy fatty acid from the Okinawan cyanobacterium <i>Okeania hirsuta</i>
Haruka Nishino, Nao Kanda, Bo-Tao Zhang, Michiya Kamio, Hajime Uchida, Kohtaro Sugahara, Hiroshi Nagai, Masayuki Satake , 2024年02月
Natural Product Research , 1 - 8
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7-<i>Epi</i>-30-methyloscillatoxin D from an Okinawan cyanobacterium <i>Okeania hirsuta</i>
Nao Kanda, Bo-Tao Zhang, Akihisa Shinjo, Mitsunobu Kamiya, Hiroshi Nagai, Hajime Uchida, Yusuke Araki, Toshio Nishikawa, Masayuki Satake , 2023年05月
Natural Product Communications , 18 (5) , 1 - 5
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Enhancement of the Antihypertensive Effect of Fermented Sargassum horneri with Lactiplantibacillus pentosus SN001.
Momoko Tamura, Satoshi Shimizu, Hiroshi Nagai, Orie Yoshinari, Naoko Hamada-Sato , 2022年07月
Fermentation , 8 (7) , 330 - 330
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Antihypertensive effects of abalone viscera fermented with Lactiplantibacillus pentosus SN0011 via angiotensin-converting enzyme inhibition
Mayu Yamanushi, Mariko Shimura, Hiroshi Nagai, Naoko Hamada-Sato , 2022年03月
Food Chemistry:X
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Aplysiadione and aplysiaenal: Truncated biosynthetic intermediates of aplysiatoxins from a cyanobacterium
Masayuki Satake, Kanon Iguchi, Ryuichi Watanabe, Hajime Uchida, Hiroshi Nagai , 2021年09月
Results in Chemistry , 3 , 100206 - 100206
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Antihypertensive and probiotic effects of Hidakakombu (Saccharina angustata) fermented by Lacticaseibacillus casei 001
Tetsuya Sekine, Hiroshi Nagai, Naoko Hamada-Sato , 2021年08月
Foods , 10 (9) , 2048 - 2048
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Evaluation of angiotensin-converting enzyme-inhibitory activity in abalone viscera fermented by Lactobacillus casei 001
Yushi Fujimura, Mariko Shimura, Hiroshi Nagai, Naoko Hamada-Sato , 2021年07月
Journal of Functional Foods , 82 , 104474 - 104474
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Isolation and structure elucidation of a novel symmetrical macrocyclic phthalate hexaester
Michiya Kamio, Weina Jiang, Hiroki Osada, Masayuki Fukuoka, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Hiroshi Nagai , 2021年02月
Symmetry , 13 (2) , 361 - 361
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Hemolytic compound 3,7,11,15-tetramethyl-hexadecan-1,19-disulfate found in the invasive European sea squirt Ascidiella aspersa
Hiroshi Nagai, Shuya Shibahara, Ryoji Matsushima, Hajime Uchida, Makoto Kanamori, Yasuyuki Nogata, Michiya Kamio , 2021年01月
Fisheries Science , 87 (1) , 145 - 150
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Debromooscillatoxins G and I from the cyanobacterium Moorea producens
Kanon Iguchi, Masayuki Satake, Yutaro Nishio, Bo-Tao Zhang, Kento Kawashima, Hajime Uchida, Hiroshi Nagai , 2021年
HETEROCYCLES , 102 (7) , 1287 - 1293
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Natural dolapyrrolidone: Isolation and absolute stereochemistry of a substructure of bioactive peptides
Ayana Murakami, Jun‐ichi Hayashi, Kazunobu Igawa, Miki Tsutsumi, Katsuhiko Tomooka, Hiroshi Nagai, Tatsuo Nehira , 2020年09月
Chirality , 32 (9) , 1152 - 1159
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Differences in the cnidomes and toxicities of the oral arms of two commercially harvested rhizostome jellyfish species in Thailand
Yusuke Kondo, Yasuko Suzuki, Susumu Ohtsuka, Hiroshi Nagai, Hayato Tanaka, Khwanruan Srinui, Hiroshi Miyake, Jun Nishikawa , 2020年08月
Journal of the Marine Biological Association of the United Kingdom , 100 (5) , 701 - 711
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Isolation, Structure Determination, and Synthesis of Cyclic Tetraglutamic Acids from Box Jellyfish Species Alatina alata and Chironex yamaguchii
Justin Reinicke, Ryuju Kitatani, Shadi Sedghi Masoud, Kelly Kawabata Galbraith, Wesley Yoshida, Ayako Igarashi, Kazuo Nagasawa, Gideon Berger, Angel Yanagihara, Hiroshi Nagai, F. David Horgen , 2020年
Molecules , 25 (4) , 883 - 883
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Neo-aplysiatoxin A isolated from Okinawan cyanobacterium Moorea producens.
Mioko Kawaguchi, Masayuki Satake, Bo-Tao Zhang, Yue-Yun Xiao, Masayuki Fukuoka, Hajime Uchida, Hiroshi Nagai , 2020年
Molecules , 25 (3) , 457 - 457
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クラゲによる刺傷被害と刺胞毒─刺胞動物の特徴である刺胞とその毒性について
永井 宏史 , 2020年
生物の科学 遺伝 , 74 , 420 - 425
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Oscillatoxin I: A new aplysiatoxin derivative, from a marine cyanobacterium
Hiroshi Nagai, Shingo Sato, Kaori Iida, Kazutaka Hayashi, Mioko Kawaguchi, Hajime Uchida, Masayuki Satake , 2019年06月
Toxins , 11 (6) , 366 - 366
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New aplysiatoxin derivatives from the Okinawan cyanobacterium <i>Moorea producens</i>
Hiroshi Nagai, Minami Watanabe, Shingo Sato, Mioko Kawaguchi, Yue-Yun Xiao, Kazutaka Hayashi, Ryuichi Watanabe, Hajime Uchida, Masayuki Satake , 2019年04月
Tetrahedron , 75 (17) , 2486 - 2494
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New aplysiatoxin derivatives from the Okinawan cyanobacterium Moorea producens.
Hiroshi Nagai, Minami Watanabe, Shingo Sato, Mioko Kawaguchi, Yue-Yun Xiao, Kazutaka Hayashi, Ryuichi Watanabe, Hajime Uchida, Masayuki Satake. , 2019年01月
Tetrahedron , 75 , 2486 - 2494
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Oscillatoxin I: A new aplysiatoxin derivative, from a marine cyanobacterium.
Hiroshi Nagai, Shingo Sato, Kaori Iida, Kazutaka Hayashi, Mioko Kawaguchi, Hajime Uchida, Masayuki Satake. , 2019年
Toxins , 11 , 366
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A new malyngamide from the marine cyanobacterium Moorea producens.
Weina Jiang, Wei Zhou, Raymie Othman, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Hiroshi Nagai , 2018年09月
Natural Products Research , 31 , 97 - 104
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沖縄産ラン藻より得られた新規アプリシアトキシン類縁体に関する報告
渡辺陽光・赤木拓也・佐藤真伍・川口美欧子・ 金山卓郎・肖越云・堤美葵・鈴木敏之・渡邊龍一・内田肇・佐竹真幸・永井宏史 , 2018年09月
第60回天然有機化合物討論会講演要旨集 , 385 - 390
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A new malyngamide from the marine cyanobacterium <i>Moorea producens</i>
Weina Jiang, Wei Zhou, Raymie Othman, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Hiroshi Nagai , 2018年01月
Natural Product Research , 32 (1) , 97 - 104
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P1-21 沖縄産ラン藻より得られた新規アプリシアトキシン類縁体
渡辺 陽光, 赤木 拓也, 佐藤 真伍, 川口 美欧子, 金山 拓郎, 肖 越云, 堤 美葵, 鈴木 敏之, 渡邊 龍一, 内田 肇, 佐竹 真幸, 永井 宏史 , 2018年
天然有機化合物討論会講演要旨集 , 60 (0) , 385-390
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Five new indole derivatives from the cyanobacterium Moorea producens
Weina Jiang, Yingyue Bu, Mioko Kawaguchi, Hiroki Osada, Masayuki Fukuoka, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Hiroshi Nagai , 2017年09月
Phytochemistry Letters , 22 , 163 - 166
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刺胞動物に特異的に存在する環状ペプチドcnidarin類
永井宏史・五十嵐文子・北谷龍樹・、内田肇・渡邊龍一・鈴木敏之・Shadi Sedghi Masoud・長澤和夫 , 2017年09月
第59回天然有機化合物討論会講演要旨集 , 585 - 590
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クラゲによる刺症: その仕組みと対処法
永井宏史 , 2017年07月
アクアネット（湊文社） , 19 , 32 - 35
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Premolt biomarker metabolite N-acetylglucosamino-1,5-lactone in female urine of the helmet crab Telmessus cheiragonus.
Hirona Yano, Michiya Kamio, Hiroshi Nagai. , 2016年09月
Biological Bulletin , 230 , 143 - 151
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Phyllosomas of the smooth fan lobsters encase nematocyst tubules of jellyfish in peritrophic membranes in their feces.
Michiya Kamio, Kaori Wakabayashi, Hiroshi Nagai, Yuji Tanaka , 2016年09月
Plankton and Benthos Research , 11 , 100 - 104
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Sequestration of dimethylsulfoniopropionate (DMSP) and acrylate from the green algae Ulva spp. by the sea hare Aplysia juliana.
Michiya Kamio, Mao Koyama, Nobuko Hayashihara, Kaori Hiei, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Hiroshi Nagai. , 2016年08月
Journal of Chemical Ecology , 42 , 452 - 460
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Development of a new diatom growth inhibition assay using XTT colorimetric method.
Weina Jiang, Takuya Akagi, Hidekazu Suzuki, Ayaka Takimoto, Hiroshi Nagai. , 2016年08月
Comp. Biochem. Physiol. Part C , 185-186 , 13 - 19
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海洋危険生物 刺されて中毒；とくにクラゲについて
永井宏史 , 2016年08月
中毒研究 日本中毒学会機関誌 , 29 , 10 - 15
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Structural optimization of 10-methyl-aplog-1, a simplified 1 analog of 2 debromoaplysiatoxin, as an anticancer lead.
Masayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie , 2016年03月
Biosci. Biotech. Biochem. , 80 , 221 - 231
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Length Is Associated with Pain: Jellyfish with Painful Sting Have Longer Nematocyst Tubules than Harmless Jellyfish
Ryujyu Kitatani,Mayu Yamada, Michiya Kamio, Hiroshi Nagai , 2015年09月
PLOS ONE , 10: e0135015 , 1 - 8
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Identification of allergens in the box jellyfish Chironex yamaguchii that cause sting dermatitis.
Takumi Horiike, Hiroshi Nagai, Seiichi Kitani , 2015年08月
International Archives of Allergy and Immunology , 167 , 73 - 82
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Comparison of cytotoxicity among pectenotoxin-2 and other oxidized pectenotoxins in a rat myoblast cell line (L6) and a human rhabdomyosarcoma cell line (RD).
Ryoji Matsushima, Saori Kikutsugi, Ryuichi Watanabe, Hajime Uchida, Takeshi Yasumoto, Hiroshi Nagai, Masaki Kaneniwa, Toshiyuki Suzuki , 2015年08月
Fundamental Toxicological Sciences , 2 , 49 - 54
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Assimilation, accumulation and metabolism of dinophysistoxins (DTXs) and pectenotoxins (PTXs) in the Japanese scallop Patinopecten yessoensis.
Ryoji Matsushim, Hajime Uchida, Satoshi Nagai, Ryuichi Watanabe, Michiya Kamio, Hiroshi Nagai, Masaki Kaneniwa, Toshiyuki Suzuki , 2015年03月
Toxins , 7 , 5141 - 5154
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Two New Lyngbyatoxin Derivatives from the Cyanobacterium Moorea producens
Weina Jiang, Satoshi Tan, Yusuke Hanaki, Kazuhiro Irie, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai. , 2014年12月
Marine Drugs , 12 , 5788 - 5800
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A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens.
Weina Jiang, Wei Zhou, Hajime Uchida, Masayuki Kikumori, Kazuhiro Irie, Ryuichi Watanabe , Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai , 2014年11月
Marine Drugs , 12 , 2748 - 2748
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A convenient HPLC method of okadaic acid analogues as 9-anthrylmethyl esters with an automatic column switching cleanup method.
Hajime Uchida, Ryuichi Watanabe, Ryoji Matsushima, Naoyuki Uchida, Hiroshi Nagai, Michiya Kamio, Takeshi Yasumoto, Toshiyuki Suzuki. , 2014年08月
Journal of AOAC International , 97 , 391 - 397
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Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.
Ryo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie , 2013年11月
Bioorganic & Medicinal Chemistry Letters , 23 , 4319 - 4323
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Evaluation of the bioactivities of water-soluble extracts from twelve deep-sea jellyfish species.
Takenori Kawabata, Dhugal J. Lindsay, Minoru Kitamura, Satoshi Konishi, Jun Nishikawa, Shuhei Nishida, Michiya Kamio, Hiroshi Nagai. , 2013年11月
Fisheries Science , 79 , 487 - 494
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LC-MS/MS analysis of palytoxin analogues in blue humphead parrotfish Scarus ovifrons causing human poisoning in Japan.
Toshiyuki Suzuki, Ryuichi Watanabe, Ryoji Matsushima, Kenji Ishihara, Hajime Uchida, Saori Kikutsugi, Tomoko Harada , Hiroshi Nagai, Masao Adachi, Takeshi Yasumoto, Masakazu Murata , 2013年08月
Food Additives & Contaminants , 30 , 1358 - 1364
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クラゲの毒に関する研究の現状
永井宏史 , 2013年03月
日本水産学会誌 , 79 , 104 - 104
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Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity. Journal of Medicinal Chemistry
Masayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie , 2012年11月
Journal of Medicinal Chemistry , 55 , 5614 - 5626
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LC-MS/MS analysis of novel ovatoxin isomers in several Ostreopsis strains collected in Japan
Toshiyuki Suzuk, Ryuichi Watanabe, Hajime Uchida, Ryoji Matsushima, Hiroshi Nagai, Takeshi Yasumoto, Takamichi Yoshimatsu, Shinya Sato, Masao Adachi. , 2012年03月
Harmful Algae , 20 , 81 - 91
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Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with anti-proliferative activity like bryostatin-1.
K. Irie, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R.C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa. , 2012年03月
Pure Appl. Chem. , 84 , 1341 - 1351
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Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin
Y. Nakagawa, M. Kikumori, R.C. Yanagita, A. Murakami, H. Tokuda, H. Nagai, K. Irie , 2011年08月
Biosci. Biotech. Biochem. , 75 , 1167 - 1173
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刺胞動物のタンパク質毒素に関する研究
永井宏史 , 2011年08月
日本水産学会誌 , ７７ , 368 - 371
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Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai, K. Irie. , 2010年10月
Bioorganic & Medicinal Chemistry Letters , 20 , 6064 - 6066
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Characterization of a new hemolytic protein toxin from the sea anemone Anthopleura asiatica.
Yuuki Kohno, Hiroshi Satoh, Akiko Iguchi and Hiroshi Nagai , 2009年08月
Fisheries Science , 75 , 1049 - 1054
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Isolation and cDNA cloning of an antibacterial L-amino acid oxidase from the skin mucus of the great sculpin Myoxochephalus polyacanthocephalus.
Yuji Nagashima, Chihiro Tsukamoto, Yoichiro Kitani, Shoichiro Ishizaki, Hiroshi Nagai and Takashi Yanagimoto , 2009年08月
Comp. Biochem. Physiol. Part B , 154 , 55 - 61
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Structual characterizatio of plancitoxin I, a deoxyribonucleases II-like lethal factor from the crown-of-thorns starfich Acanthaster planci, by expression in Chinese hamster ovary cells.
Ai Watanabe, Hiroshi Nagai, Yuji Nagashima and Kazuo Shiomi , 2009年08月
Fisheries Science , 75 , 225 - 331
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A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
Yu Nakagawa, Ryo C. Yanagita, Naoko Hamada, Akira Murakami, Hideyuki Takahashi, Naoaki Saito, Hiroshi Nagai and Kazuhiro Irie , 2009年08月
Journal of the American Chemical Society , 131 , 7573 - 7579
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JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.
T. Fujiwara, J.H. Hwang, A. Kanamoto, H. Nagai, M. Takagi and K. Shin-Ya , 2009年08月
Journal of Antibiotics , 62 , 393 - 395
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Isolation and characterization of a novel protein toxin from fire coral.
Akiko Iguchi, Setsuko Iwanaga and Hiroshi Nagai. , 2008年09月
Biochem. Biophys. Res. Commun. , 365 , 107 - 112
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Novel peptide toxins from the sea anemone Stichodactyla haddoni
Tomohiro Honma, Shino Kawahata, Masami Ishida, Hiroshi Nagai, Yuji Nagashima and Kazuo Shiomi , 2008年09月
Peptides , 29 , 536 - 544
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Purification and Seaching for Bioactive Water-Soluble Compounds from Marine Sponges.
Kosaku Ito, Atsushi Tsuruta, Keiji Takahara, Satoko Matayoshi and Hiroshi Nagai , 2008年08月
Proceedings of the WFC2008 (5th World Fisheries Congress) , 3g-0678-483 (CD) , 0 - 0
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Purification and molecular cloning of SE-cephalotoxin, a novel proteinaceous toxin from the posterior salivary gland of cuttlefish Sepia esculenta.
Atsushi Ueda, Hiroshi Nagai, Masami Ishida, Yuji Nagashima and Kazuo Shiomi. , 2008年04月
Toxicon , 52 , 574 - 581
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2. Yoichiro Kitani, Tsukasa Mori, Hiroshi Nagai, Keiko Toyooka, Shoichiro Ishizaki, Kuniyoshi Shimakura, Kazuo Shiomi and Yuji Nagashima. Gene expression and distribution of antibacterial l-amino acid oxidase in the rockfish Sebastes schlegeli.
Yoichiro Kitani, Tsukasa Mori, Hiroshi Nagai, Keiko Toyooka, Shoichiro Ishizaki, Kuniyoshi Shimakura, Kazuo Shiomi and Yuji Nagashima. , 2007年12月
Fish and Shellfish Immunology , 23 , 1178 - 1186
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Characterization of PsTX-60B, a new membrane-attack complex/perforin (MACPF) family toxin, from the venomous sea anemone Phyllodiscus semoni.
Hiroshi Satoh, Naomasa Oshiro, Setsuko Iwanaga, Michio Namikoshi and Hiroshi Nagai , 2007年08月
Toxicon , 49 , 1208 - 1210
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Identification of an antibacterial protein as L-amino acid oxidase in the skin mucus of rockfish Sebastes schlegeli.
Y. Kitani, C. Tsukamoto, G.H. Zhang, H. Nagai, M. Ishida, S. Ishizaki, K. Shimakura, K. Shiomi and Y. Nagashima , 2007年08月
FEBS Journal , 274 , 125 - 136
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アナサンゴモドキ(Millepora dichotoma)が有する機能性タンパク質分子
井口聡子・岩永節子・永井宏史 , 2007年04月
第49回天然有機化合物討論会講演要旨集 , 335 - 340
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Four new macrocyclic tricothecenes from two strains of marine-derived fungi of the genus Myrothecium.
J. Xu, A. Takasaki, H. Kobayashi, T. Oda, J. Yamada, R.E.P. Mnagindaan, K. Ukai, H. Nagai and M. Namikoshi , 2006年01月
Journal of Antibiotics , 59 , 451 - 455
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Molecular cloning of two toxic phospholipases A2 from the crown-of-thorns starfish Acanthaster planci venom.
E. Ota, H. Nagai, Y. Nagashima and K. Shiomi , 2006年01月
Comparative Biochemistry and Physiology. Part B , 143 , 54 - 60
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Purification, properties and cDNA cloning of neoverrucotoxin (neoVTX), a hemolytic lethal factor from the stonefish Synanceia verrucosa venom.
A. Ueda, M. Suzuki, T. Honma, H. Nagai, Y. Nagashima and K. Shiomi , 2006年01月
Biochimica et Biophysica Acta , 1760 , 1713 - 1722
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New cyclic depsipeptides from the green alga Bryopsis species; application of a carboxypeptidase hydrolysis reaction to the structure determination.
A. Dmitrenok, T. Iwashita, T. Nakajima, B. Sakamoto, M. Namikoshi and H. Nagai , 2006年01月
Tetrahedron , 62 , 1301 - 1308
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Melophlins P, Q, R, and S, four new tetramic acid derivatives, from two Palauan marine sponges of the genus Melophlus.
J. Xu, M. Hasegawa, K. Harada, H. Kobayashi, H. Nagai and M. Namikoshi , 2006年01月
Chemical and Phramaceutical Bulletin , 54 , 852 - 854
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Isolation and cDNA cloning of a potassium channel peptide toxin from the sea anemone Anemonia erythraea.
Y. Hasegawa, T. Homma, H. Nagai, M. Ishida, Y. Nagashima and K. Shiomi , 2006年01月
Toxicon , 48 , 536 - 542
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Isolation and molecular cloning of novel peptide toxins from the sea anemone Antheopsis maculata.
T. Homma, Y. Hasegawa, M. Ishida, H. Nagai, Y. Nagashima and K. Shiomi , 2005年01月
Toxicon , 45 , 33 - 41
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Lissoclibadins 1?3, three new polysulfur alkaloids, from the ascidian Lissoclinum cf. badium.
H. Liu, T. Fujiwara, T. Nishikawa, Y. Mishima, H. Nagai, T. Shida, K. Tachibana, H. Kobayashi, R.E.P. Mangindaan and M. Namikoshi , 2005年01月
Tetrahedron , 61 , 8611 - 8615
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Novel peptide toxins from acrorhagi, aggressive organs of the sea anemone Actinia equina.
T. Honma, S. Minagawa, H. Nagai, M. Ishida, Y. Nagashima and K. Shiomi , 2005年01月
Toxicon , 46 , 768 - 774
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Novel peptide toxins from acrorhagi, aggressive organs of the sea anemone Actinia equina.
T. Honma, S. Minagawa, H. Nagai, M. Ishida, Y. Nagashima and K. Shiomi , 2005年01月
Toxicon , 46 , 768 - 774
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Seven new meroditerpenoids, from the marine sponge Strongylophora strongylata, that inhibited the maturation of starfish oocytes.
H. Liu, M. Namikoshi, K. Akano, H. Kobayashi, H. Nagai and X. Yao , 2005年01月
Journal of Asian Natural Products Research , 7 , 661 - 670
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Manoalide derivatives from a marine sponge Luffariella sp. collected in Palau.
M. Namikoshi, S. Suzuki, S. Meguro, H. Nagai, Y. Koike, A. Kitazawa, H. Kobayashi, T. Oda and J. Yamada , 2004年01月
Fisheries Science , 70 , 152 - 158
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Lissoclibadin 1, a novel trimeric sulfur-bridged dopamine derivative, from the tropical ascidian Lissoclinum cf. badium.
H. Liu, S.B. Pratasik, T. Nishikawa, T. Shida, K. Tachibana, T. Fujiwara, H. Nagai, H. Kobayashi and M. Namikoshi , 2004年01月
Tetrahedron Letters , 45 , 7015 - 7017
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Biosynthesis and transformation of homoanatoxin-a in the cyanobacterium Raphidiopsis mediterranea Skuja and structures of three new homologues.
M. Namikoshi, T. Murakami, T. Fujiwara, H. Nagai, T. Niki, E. Harigaya, M.F. Watanabe, T. Oda, J. Yamada and S. Tsujimura , 2004年01月
Chemical Research in Toxicology , 17 , 1692 - 1696
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Plancitoxins, lethal factors from the crown-of-thorns starfish Acanthaster planci, are deoxyribonucleases II.
K. Shiomi, S. Midorikawa, M. Ishida, Y. Nagashima and H. Nagai , 2004年01月
Toxicon , 44 , 499 - 506
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Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtuble assembly from a marine sponge Phyllospongia dendyi collected at Palau.
K. Tachibana, T. Fujiwara, H. Nagai, H. Kobayashi and M. Namikoshi , 2004年01月
Journal of Natural Products , 67 , 472 - 474
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A new membrane-attack complex/ perforin (MACPF) domain lethal toxin from the nematocyst venom of the Okinawan sea anemone Actineria villosa.
N. Oshiro, C. Kobayashi, S. Iwanaga, M. Nozaki, M. Namikoshi, J. Spring and H. Nagai , 2004年01月
Toxicon , 43（5） , 225 - 228
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Isolation of araguspongine M, a new stereoisomer of araguspongine/xestospongin alkaloid, and dopamine from the marine sponge Neopetrosia exigua collected in Palau.
H. Liu, Y. Mishima, T. Fujiwara, H. Nagai, A. Kitazawa, Y. Mine, H. Kobayashi, X. Yao, J. Yamada, T. Oda and M. Namikoshi , 2004年01月
Marine Drugs , 2 , 154 - 163
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Molecular cloning of an epidermal growth factor-like toxin and two sodium channel toxins from the sea anemone Stichodactyla gigantean
Tomohiro Honma, Hiroshi Nagai, Yuji Nagashima and Kazuo Shiomi , 2003年01月
Biochim. Biophys. Acta. , 1652 , 103 - 106
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Three New Chlorine Containing Antibiotics from a Marine-derived Fungus Aspergillus ostianus Collected in Phonpei.
Michio Namikoshi, Rika Negishi, Hiroshi Nagai, Andrey Dmitrenok and Hisayoshi Kobayashi , 2003年01月
Journal of Antibiotics , 56 , 755 - 761
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Simultaneous production of homoanatoxin-a, anatoxin-a, and a new non-toxic 4-hydroxyhomoannatoxin-a by the cyanobacterium Raphidiopsis mediterranea Skuja.
Michio Namikoshi, Tomokazu Murakami, Mariyo F. Watanabe, Taiko Oda, Junko Yamada, Shigeo Tsujimura, Hiroshi Nagai and Shinshi Oishi , 2003年01月
Toxicon , 42 , 533 - 538
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A Trial of MASS Spectrometric Characterization on Novel Animal Toxins in Femto-molar Amount from the Subtoropical Islands.
Terumi Nakajima, Hideo Naoki, Gerardo Corzo, Dai Li, Miki Hisada, Pierre Escoubas, Naoko Yamaji, Hiroshi Nagai, Akikazu Yasuda, Marta Andrianstiferana, Joachim Haupt, and Naomasa Ohshiro , 2003年01月
J. Toxicol-Toxin Rev. , 22 , 509 - 520
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Primary structure of echotoxin 2, an actinoporin-like hemolytic toxin from the salivary gland of the marine gastropod Monoplex echo.
Yoko Kawashima, Hiroshi Nagai, Masami Ishida, Yuji Nagashima and Kazuo Shiomi. , 2003年01月
Toxicon , 42 , 491 - 497
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Recent Progress in Jellyfish Toxin Study.
Hiroshi Nagai , 2003年01月
Journal of Health Science , 49 , 337 - 340
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Novel Proteinaceous Toxins from the Nematocyst Venom of the Okinawan Sea Anemone Phyllodicus semoni Kwietniewski.
Hiroshi Nagai, Naomasa Oshiro, Kyoko Takuwa-Kuroda, Setsuko Iwanaga, Masatoshi Nozaki and Terumi Nakajima , 2002年12月
Biochemical and Biophysical Research Communications, , 294 , 760 - 763
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A Novel Toxin from the Deadly Box Jellyfish (Sea Wasp, Habu-kurage) Chiropsalmus quadrigatus.
Hiroshi Nagai, Kyoko Takuwa-Kuroda, Masahiro Nakao, Naomasa Oshiro, Setsuko Iwanaga and Terumi Nakajima , 2002年08月
Bioscience, Biotechnology, and Biochemistry , 66 , 97 - 102
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刺胞動物由来の高分子タンパク質毒素
永井宏史 , 2002年07月
第37回天然物化学談話会講演要旨集 , 1 - 6
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Polyhydroxysteroids and Saponins of Asterina pectinifera Prevent Desquamatiom from Stratum Corneum.
Kazuko Ukai, Atsufumi Iwanaga, Hiroshi Nagai and Michio Namikoshi , 2002年04月
Bioscience, Biotechnology, and Biochemistry , 66 , 913 - 915
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刺胞動物のタンパク質毒素（特に立方クラゲの毒素について）
永井宏史 , 2002年03月
“みどりいし” , 13 , 15 - 18
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A New Actinoporin-type Polypeptide Toxin from the Nematocyst Venom of the Okinawan Sea Anemone Phyllodiscus semoni (Japanese name “unbachi-isoginchaku”).
Hiroshi Nagai, Naomasa Oshiro, Kyoko Takuwa-Kuroda, Setsuko Iwanaga, Masatoshi Nozaki, Terumi Nakajima , 2002年01月
Biosci. Biotech. Biochem. , 66 , 2621 - 2625
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沖縄産ハブクラゲ(Chiropsalmus quadrigatus)刺胞毒の化学的性状
永井宏史、宅和京子、大城直雅、岩永節子、中嶋暉躬 , 2001年10月
第43回天然有機化合物討論会講演要旨集 , 401 - 406
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立方クラゲ類のタンパク質毒素の化学的性状
永井宏史、宅和京子、中嶋暉躬 , 2001年07月
第48回毒素シンポジウム予稿集 , 65 - 70
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Protein Toxins from Stinging Cnidarians
Hiroshi Nagai , 2001年06月
Abstract of 10th International Symposium on Marine Natural Products , 36 - 36
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New Malyngamides from the Hawaiian Cyanobacterium Lyngbya majuscula.
Yukiko Kan, Bryan Sakamoto, Tsuyoshi Fujita and Hiroshi Nagai , 2000年12月
Journal of NaturalProducts , 63 , 1599 - 1602
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Isolation and Characterization of a Novel Protein Toxin from the Hawaiian Box Jellyfish (Sea Wasp) Carybdea alata.
Hiroshi Nagai, Kyoko Takuwa, Masahiro Nakao, Bryan Sakamoto, Gerald L. Crow and Terumi Nakajima , 2000年12月
Biochemical and Biophysical ResearchCommunications , 275 , 589 - 594
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21 Novel ProteinaceousToxins from the Box Jellyfish (Sea Wasp) Carybdea rastoni.
Hiroshi Nagai, Kyoko Takuwa, Masahiro Nakao, Emiko Ito, Masami Miyake, Masatoshi Noda and Terumi Nakajima , 2000年12月
Biochemical andBiophysical ResearchCommunications , 275 , 582 - 588
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The Absolute Configuration of Gambieric Acids A-D, Potent Antifungal Polyethers, Isolated from the Marine Dinoflagellate Gambierdiscus toxicus.
Akio Morohashi, Masayuki Satake, Hiroshi Nagai, Yasukatsu Oshima and Takeshi Yasumoto , 2000年11月
Tetrahedron , 56 , 8995 - 9001
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初めて明らかにされたクラゲ毒の化学的性状（アンドンクラゲから得られたタンパク質毒素
永井宏史 , 2000年11月
“バイオサイエンスとインダストリー” , 58 , 43 - 44
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ハワイ産立方クラゲCarybdea alataの刺胞毒の化学的性状
永井宏史、宅和京子、中嶋暉躬 , 2000年10月
第42回天然有機化合物討論会講演要旨集 , 391 - 396
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Isolation of a Sulfoquinovosyl Monoacylglycerol from Bryopsis sp. (Chlorophyta): Identification of a Factor Causing Possible Species-Specific Ecdysis Response in Gambierdiscus toxicus(Dinophyceae).
Bryan Sakamoto, Yoshitsugi Hokama, F. David Horgen, Paul J. Scheuer, Yukiko Kan and Hiroshi Nagai , 2000年09月
Journal of Phycology , 36 , 924 - 931
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26. A New Depsipeptide from the Sacoglossan Mollusk Elysia ornata and the Green Alga Bryopsis sp.
F.David Horgen, Derrik B. delos Santos, Gilles Goetz, Bryan Sakamoto, Yukiko Kan, Hiroshi Nagai, Paul J. Scheuer , 2000年01月
Journal of Natural Products , 63 , 152 - 154
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Bleeding from the small intestine caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning
Emiko Ito and Hiroshi Nagai , 2000年01月
Toxicon , 38 , 123 - 132
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アンドンクラゲ刺毒の化学的性状に関する研究
永井宏史、宅和京子、中嶋暉躬、中尾正宏、伊藤恵美子、三宅眞実、野田公俊 , 1999年10月
第41回天然有機化合物討論会講演要旨集 , 259 - 264
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Kahalalide K: A New Cyclic Depsipepide from the Hawaiian Green Alga Bryopsis Species.
Yukiko Kan, Tsuyoshi Fujita Yoshitsugi Hokama, Bryan Sakamoto and Hiroshi Nagai , 1999年08月
Journal of NaturalProducts , 62 , 1169 - 1172
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クラゲ由来の未知なる高分子タンパク毒素の化学
永井宏史 , 1999年08月
第11回名古屋コンファレンス：未解明生物現象の化学-新世紀の機能分子を求めて-講演要旨集 , 7 - 8
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野外で見られたアンドンクラゲ（立方クラゲ綱、アンドンクラゲ科）の生態的希少例
大石博人、永井宏史、久保田信、上野俊士郎 , 1999年06月
南紀生物 , 41 , 49 - 50
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ハワイで発生したオゴノリ食中毒：ラン藻毒アプリシアトキシン類による初めての中毒事例。
永井宏史 , 1999年03月
“化学と生物” , 37 , 149 - 151
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Malyngamides M and N from the Hawaiian Red Alga Gracilaria coronopifolia.
Yukiko Kan, Tsuyoshi Fujita, Hiroshi Nagai, Bryan Sakamoto and Yoshitsugi Hokama , 1998年12月
Journal of Natural Products , 61 , 152 - 155
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Morphological Observations of Diarrhea in Mice Caused by Aplysiatoxin, the Causative Agent of the Red Alga Gracilaria coronopifolia poisoning in Hawaii.
Emiko Ito and Hiroshi Nagai , 1998年12月
Toxicon , 36 , 1913 - 1920
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The Absolute Stereochemistry of Manauealide C, a Toxic Constituent in the Hawaiian Red Alga Gracilaria coronopifolia.
Hiroshi Nagai, Yukiko Kan, Tsuyoshi Fujita, Bryan Sakamoto and Yoshitsugi Hokama , 1998年12月
Bioscience, Biotechnology,and Biochemistry , 62 , 1011 - 1013
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The Possible Role of Gambieric acid-A as an Autocrine Type Growth Stimulator of Gambierdiscus toxicus.
編：B. Reguera、著：Bryan Sakamoto, Hiroshi Nagai and Yoshitsugi Hokama , 1998年10月
"Harmful Microalgae" , 370 - 371
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. Manauealides, Some of the Causative Agents of a Red Alga Gracilaria coronopifolia Poisoning in Hawaii
Hiroshi Nagai, Takeshi Yasumoto and Yoshitsugi Hokama , 1997年12月
Journal of Natural Products , 60 , 925 - 928
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微細藻類の生態制御に関与する物質
永井宏史 , 1997年11月
文部省科学研究補助金特別推進研究( 2)“超活性海洋天然物の精密構造解析”成果発表及び招待シンポジウム 第一回海洋生物の生理・生態の化学基盤講演要旨集 , 36 - 37
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The Causative Agents of the Red Alga Gracilaria coronopifolia. poisoning in Hawaii.
Hiroshi Nagai , 1997年10月
“The 9th Naito Conference on Bioactive Natural Products and Their Modes of Action.” , 91 - 91
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Aplysiatoxin and debromoaplysiatoxin as the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii．
Hiroshi Nagai，Takeshi Yasumoto and Yoshitsugi Hokama , 1996年12月
Toxicon , 34 , 753 - 761
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Growth and cyclic studies of Gambierdiscus toxicus in the natural environment and in culture．
Yoshitsugi Hokama, Joanne S.M. Ebesu, Daisy A. Asuncion and Hiroshi Nagai , 1996年07月
“Harmful and Toxic Algal Blooms” , 313 - 315
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Stimulators of Gambierdiscus toxicus（Dinophyceae）growth：the possible role of gambieric acid‐A as an endogenous growth enhancer．
Bryan Sakamoto, Hiroshi Nagai and Yoshitsugi Hokama , 1996年04月
Phycologia , 35 , 350 - 353
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Antifungals produced by dinoflagellates‐gambieric acids．
Hiroshi Nagai, Yuzuru Mikami and Takeshi Yasumoto , 1995年12月
Pesticide Science , 44 , 92 - 94
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Sodium channel inhibitor（SCl） toxin(s) and maitotoxin or palytoxin like compounds in extracts of herbivore gut and algae as assessed by mouse and guinea pig atrial assays．
Y. Hokama, Joanne S.M. Ebesu, J.L.R.Y. Shirai, H. Nagai and J.T. Miyahara , 1995年11月
“Proceedings of the lnternational Symposium on Ciguatera and Marine Natural Products” , 51 - 72
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Action of maitotoxin with Na+/K+-ATPase on erythrocyte and neuroblastoma cells.
Hiroshi Nagai, Yoshitsugi Hokama and Takeshi Yasumoto , 1995年11月
“Proceedings of the lnternational Symposium on Ciguatera and Marine Natural Products” , 277 - 282
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Outbreak of Gastrointestinal illness associated with consumption of seaweed‐Hawaii，1994．
M．Hanne, H. Matsubayashi, R. Vogt, C. Wakida, S. Hau, H. Nagai, Y. Hokama, and L. Solorzano , 1995年10月
Morbidity and Mortality Weekly Report , 44 , 724 - 727
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Human intoxications from Hawaiian reef fishes associated with diverse marine toxins．
Y．Hokama, J.S.M. Ebesu, K. Nishimura, S. Oishi, B. Mizuo, M. Stiles, B. Sakamoto, W. Takenaka and H. Nagai , 1995年04月
Journal of Natural Toxins , 5 , 235 - 247
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海洋微細藻類の生理活性物質
安元健、永井宏史 , 1995年03月
平成６年度農業バイオテクノロジー関連技術情報調査報告書 , 1 - 10
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Inhibition of specific binding of okadaic acid to protein phosphatase 2 A by mycrocystin‐LR, calyculin‐A，and tautomycin：method of analysis of interaction of tight‐binding ligands with target protein
Akira Takai, Katsunori Sasaki, Hiroshi Nagai, Gottfried Mieskes, Minoru Isobe and Takeshi Yasumoto , 1995年02月
Biochemical Journal , 306 , 657 - 665
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The first reported case of human ciguatera due to a farm‐cultured salmon．
Joanne S. M．Ebesu, Hiroshi Nagai and Yoshitsugi Hokama , 1994年10月
Toxicon , 32 , 1282 - 1286
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Three new reduce anthracycline related compounds from pathogenic Nocardia brasilienseis．
Akio Maeda，Hiroshi Nagai, Katsukiyo Yazawa, Yasushi Tanaka, Tamae Imai and Yuzuru Mikami , 1994年09月
Journal of Antibiotics , 47 , 976 - 981
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logical activities of novel polyether antifungals，gambiericacids A and B from a marine dinoflagellate Gambierdiscus toxicus．
Hiroshi Nagai, Yuzuru Mikami, Katsukiyo Yazawa, Tohru Gonoi and Takeshi Yasumoto , 1993年12月
Journal of Antibiotics , 46 , 520 - 522
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A turning point in ciguatera study.
Takeshi Yasumoto, Masayuki Satake, Masakazu Fukui, Hiroshi Nagai, Michio Murata and Anne-marie Legrand , 1993年10月
"Toxic Phytoplankton Blooms in the Sea" , 455 - 461
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Bioactive polyethers from marine dinoflagellates．
Takeshi Yasumoto, Michio Murata, Masayuki Satake and Hiroshi Nagai , 1993年07月
Gazzetta Chimica Italiana , 123 , 367 - 370
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Gambieric acids：unprecedented potent antifungal substances isolated from cultures of a marine dinoflagellates Gambierdiscus toxicus．
Hiroshi Nagai, Koichiro Torigoe, Masayuki Satake, Michio Murata, Takeshi Yasumoto and Hiroshi Hirota , 1992年12月
Journal of the American Chemical Society , 114 , 1102 - 1103
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Gambieric acids，new potent antifungal substances with unprecedented polyether structures from a marine dinoflagellate Gambierdiscus toxicus
Hiroshi Nagai, Michio Murata, Koichiro Torigoe, Masayuki Satake and Takeshi Yasumoto , 1992年12月
Journal of Organic Chemistry , 57 , 5448 - 5453
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シガテラの毒化原因渦鞭毛藻Gambierdiscus toxicusの生産する抗カビ成分gambieric acids.
永井宏史、鳥越浩一郎、佐竹真幸、村田道雄、廣田洋 , 1991年10月
第33回天然有機化合物討論会講演要旨集 , 619 - 626
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Antimicrobial activities of polyethercompounds of dinoflagellate origins．
Hiroshi Nagai．Masayuki Satake and Takeshi Yasumoto , 1990年12月
Journal of AppliedPhycology , 2 , 305 - 308
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Screening of marine phytoplankton for antifungal substances.
Hiroshi Nagai, Masayuki Satake, Michio Murata and Takeshi Yasumoto , 1990年06月
“Toxic Marine Phytoplankton” , 385 - 390
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Marine phytoplanktons as a new source of bioactive polyethers．
T．Yasumoto, M. Murata, M. Satake and H. Nagai , 1989年10月
“Current Topics in Marine Biotechnology” , 191 - 194
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Bacterial production of tetrodotoxin and its derivatives.
Takeshi Yasumoto, Amane Endo, Daisuke Yasumura, Hiroshi Nagai, Michio Murata and Mari Yotsu , 1987年06月
“Progress in Venom and Toxin Research” , 310 - 313
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Interspecies distribution and possible origin of tetrodotoxin.
T. Yasumoto, H. Nagai, D. Yasumura, T. Michishita, A. Endo, M. Yotsu and Y. Kotaki , 1986年08月
Annuals of the New York Academy of Sciences, “Tetrodotoxin Saxitoxin and the Molecular Biology of the Sodium Channel”,The New York Academy of Sciences , 479 , 44 - 51