Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Okeaniazole A: Thiazole-containing cyclopeptide from the marine cyanobacterium <i>Okeania hirsuta</i> with antileishmanial activity

  Botao Zhang, Ryoya Kawabe, Michiya Kamio, Hajime Uchida, Natsuki Matsuura, Kanami Mori-Yasumoto, Masayuki Satake, Hiroshi Nagai , 2024.10

  Tetrahedron Letters

  DOI

• (10<i>E</i>,15<i>Z</i>)-12-(Dimethylsulfonio)-9,13-dihydroxyoctadeca-10,15-dienoate

  Haruka Nishino, Bo-Tao Zhang, Hajime Uchida, Michiya Kamio, Hiroshi Nagai, Masayuki Satake , 2024.03

  Molbank

  DOI

• <i>N</i>-Desmethylmajusculamide B, a lipopeptide isolated from the Okinawan cyanobacterium <i>Okeania hirsuta</i>

  Bo-Tao Zhang, Haruka Nishino, Ryoya Kawabe, Michiya Kamio, Ryuichi Watanabe, Hajime Uchida, Masayuki Satake, Hiroshi Nagai , 2024.02

  Bioscience, Biotechnology, and Biochemistry

  DOI

• N-Desmethylmajusculamide B, a lipopeptide isolated from the Okinawan cyanobacterium Okeania hirsuta

  Zhang Bo-Tao, Nishino Haruka, Kawabe Ryoya, Kamio Michiya, Watanabe Ryuichi, Uchida Hajime, Satake Masayuki, Nagai Hiroshi , 2024.02

  Bioscience, Biotechnology, and Biochemistry

• Okeanic acid-A, a trihydroxy fatty acid from the Okinawan cyanobacterium <i>Okeania hirsuta</i>

  Haruka Nishino, Nao Kanda, Bo-Tao Zhang, Michiya Kamio, Hajime Uchida, Kohtaro Sugahara, Hiroshi Nagai, Masayuki Satake , 2024.02

  Natural Product Research

  DOI

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Books 【 display / non-display 】

Books 【 display / non-display 】

• 海洋天然物化学

  永井宏史 , 2023.08

  日本化学会編;木越英夫編著; 共立出版 , 第11章 タンパク質毒素クラゲ毒 , 0-0

• 刺す！ 咬む！ 防御する！ 猛毒をもつ危険生物

  永井宏史 , 2022.11

  誠文堂新光社 , まえがき、2章 海洋生物、 5章 生物の毒のしくみ、おわりに , 0-0

• 世界で一番美しいクラゲ図鑑

  永井宏史 , 2022.04

  誠文堂新光社 , クラゲによる刺症について , 0-0

• 夏の終わりの海にクラゲがいるのはなぜ？ 「生きもののふしぎなお話　なぜ？どうして？」

  永井　宏史 , 2019

  誠文堂新光社

• 生きもののふしぎなお話

  永井宏史 , 2019

  自然史学会連合監修;誠文堂新光社 , 夏の終わりの海にクラゲがいるのはなぜ？ , 68-69

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• 刺胞動物が持つ「刺胞」による「化学攻撃」の詳細解明

  Project Period (FY)： 2022/04  -  2026/03  Investigator(s): 永井宏史

  Grant-in-Aid for Scientific Research(C)  Principal Investigator  22K05817 

• Why Does a Venomous Jellyfish Sting Hurt? Understanding the Nature of Pain from Stings Caused by Marine Dangerous Organisms

  Project Period (FY)： 2019/04  -  2022/03  Investigator(s): NAGAI HIROSHI

  Grant-in-Aid for Scientific Research(C)  Principal Investigator  19K06220 

  Many dangerous marine organisms, such as jellyfish, cause severe pain to humans when they are touched. However, until now, there has been little scientific study to explore the reasons why this pain occurs. Therefore, our research group has researched for pain-producing compounds in species that cause pain to humans. As a result, we have succeeded in isolating several interesting compounds and determining their structures.

• Pain causative agents from marine animals

  Project Period (FY)： 2016/04  -  2019/03  Investigator(s): Nagai Hiroshi

  Grant-in-Aid for Scientific Research(C)  Principal Investigator  16K01911 

  Among the dangerous marine animals, the box jellyfish Habu-kurage is known with its severe stinging. The causative agents of severe pain by Habu-kurage were researched. Nematocyst was isolated from Habu-kurage, at first. Then, isolated nematocysts were extracted and the pure nematocyst contents were obtained. Now we are trying to isolate the pain causative agents from the isolated nematocysts of Habu-kurage. One of the Okinawan cyanobacteria is known as the causative organism of skin irritation. The skin irritation is caused by the toxins such as aplysiatoxins and lyngbyatoxins. We conducted the isolation of the cytotoxic compounds from this cyanobacterium. Finally, some new aplysiatoxin derivatives have been isolated and structurally elucidated. Also biological activity tests were accomplished on these new compounds.

• 共生系における大型クラゲ類の生態的機能

  Project Period (FY)： 2013/04  -  2016/03 

  Grant-in-Aid for Scientific Research(B)  Co-Investigator  25304031 

• 未利用海洋生物資源に由来する「刺胞」からの新規機能性分子の創出

  Project Period (FY)： 2012/04  -  2015/03 

  Grant-in-Aid for Scientific Research(C)  Principal Investigator  24510294 

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Lesson Subject 【 display / non-display 】

Lesson Subject 【 display / non-display 】