Details of a Researcher - KOBYASHI Yukihiro

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KOBYASHI Yukihiro

Job title: Assistant Professor

Department: Department of Food Science and Technology

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当科のアニサキスアレルギー3症例のコンポーネント解析 : 既存報告10症例との比較も含め

田村誠朗, 嶋倉邦嘉, 小林征洋, 吉川卓宏, 橋本哲平, 東直人, 松井聖 , 2023.11

アレルギー = Japanese journal of allergology
圧力鍋による調理で低アレルゲン化して、サバが摂取可能となった魚アレルギーの1例

平瀬敏志, 小林征洋 , 2022.12

日本小児臨床アレルギー学会誌
経皮感作により発症したと考えられた魚アレルギーの1症例

田村誠朗, 小林征洋, 松井聖 , 2022.12

アレルギーの臨床
原著魚アレルギーの7例における臨床的特徴およびアレルゲンコンポーネントについての検討

横山大輔, 足立厚子, 梅村薫, 原田朋佳, 竹内千尋, 今村忍, 一角直行, 小林征洋 , 2022.10

臨床皮膚科

DOI
Specific immunoglobulin E to Ani s 1 is rare in patients with Anisakis allergy living in Hokkaido, northern Japan

Yoshikawa Momoko, Sumikawa Yasuyuki, Kobayashi Yukihiro, Uhara Hisashi , 2022

Allergology International

DOI

魚類アレルゲン（パルブアルブミン）の耐熱性に関わる因子の解明

Project Period (FY)： 2023/04 - 2028/03 Investigator(s): 小林征洋

Grant-in-Aid for Scientific Research(C) Principal Investigator 23K05392
Study of conformational IgE-binding epitopes of fish allergen, parvalbumin

Project Period (FY)： 2020/04 - 2023/03 Investigator(s): KOBAYASHI Yukihiro

Grant-in-Aid for Scientific Research(C) Principal Investigator 20K06236

We analyzed the IgE-binding sites (epitopes) of parvalbumin (PV), a major allergen in teleost fish. Teleost fish have multiple homologous genes of PV (pvalb), but only pvalb1 to pavalb4 are highly expressed in muscle, and all allergenic PVs belong to these 4 genes. These homologous genes were likely generated by gene duplication after other vertebrates diverged from teleost fish. In addition, these genes were not found in non-allergen PVs of teleost fish or PVs of other organisms. The epitope and co-located residues were conserved in pvalb1 to pavalb4 of teleost fish, and were, however, frequently mutated in other organisms. The electrostatic potentials of these residues on the molecular surface were similar among teleost fish, but differed frequently among the other organisms.
魚類主要アレルゲンパルブアルブミンのアレルギー反応性の低減化法に関する研究

Project Period (FY)： 2013/04 - 2016/03

Grant-in-Aid for Young Scientists(B) Principal Investigator 25750023