Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• 原著 魚アレルギーの7例における臨床的特徴およびアレルゲンコンポーネントについての検討

  横山 大輔, 足立 厚子, 梅村 薫, 原田 朋佳, 竹内 千尋, 今村 忍, 一角 直行, 小林 征洋 , 2022.10

  臨床皮膚科

  DOI

• Specific immunoglobulin E to Ani s 1 is rare in patients with Anisakis allergy living in Hokkaido, northern Japan

  Yoshikawa Momoko, Sumikawa Yasuyuki, Kobayashi Yukihiro, Uhara Hisashi , 2022

  Allergology International

  DOI

• A parvalbumin allergy case was successfully treated with oral immunotherapy using hypoallergenic fish

  Ugajin T, Kobayashi Y, Yokozeki H , 2021.04

  Allergology International

  DOI

• 障害者施設での菓子製造におけるアレルゲン混入の実態と防止策

  藤野柾也, 小林征洋, 小川美香子 , 2020

  フードシステム研究

  DOI

• A CASE OF ANAPHYLAXIS CAUSED BY LANDLOCKED AYU FISH, KOAYU FISH, FROM LAKE BIWA

  Umekoji-Hayashi, A., Fukai, K., Kobayashi, Y. , 2020

  Arerugi = [Allergy]

  DOI

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Books 【 display / non-display 】

Books 【 display / non-display 】

• ウィルス・細菌・真菌・寄生虫同定便覧

  小林征洋 , 2014.05

  技術情報協会 , 第３節 線虫類 Anisakis , 406-408

• 魚介類アレルゲンの科学（水産学シリーズ164）

  小林征洋 , 2010.04

  恒星社厚生閣 , ５章 アニサキスアレルゲンの本体と性状 , 60-71

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• 魚類アレルゲン（パルブアルブミン）の耐熱性に関わる因子の解明

  Project Period (FY)： 2023/04  -  2028/03  Investigator(s): 小林 征洋

  Grant-in-Aid for Scientific Research(C)  Principal Investigator  23K05392 

• Study of conformational IgE-binding epitopes of fish allergen, parvalbumin

  Project Period (FY)： 2020/04  -  2023/03  Investigator(s): KOBAYASHI Yukihiro

  Grant-in-Aid for Scientific Research(C)  Principal Investigator  20K06236 

  We analyzed the IgE-binding sites (epitopes) of parvalbumin (PV), a major allergen in teleost fish. Teleost fish have multiple homologous genes of PV (pvalb), but only pvalb1 to pavalb4 are highly expressed in muscle, and all allergenic PVs belong to these 4 genes. These homologous genes were likely generated by gene duplication after other vertebrates diverged from teleost fish. In addition, these genes were not found in non-allergen PVs of teleost fish or PVs of other organisms. The epitope and co-located residues were conserved in pvalb1 to pavalb4 of teleost fish, and were, however, frequently mutated in other organisms. The electrostatic potentials of these residues on the molecular surface were similar among teleost fish, but differed frequently among the other organisms.

• 魚類主要アレルゲンパルブアルブミンのアレルギー反応性の低減化法に関する研究

  Project Period (FY)： 2013/04  -  2016/03 

  Grant-in-Aid for Young Scientists(B)  Principal Investigator  25750023 

Lesson Subject 【 display / non-display 】

Lesson Subject 【 display / non-display 】