Details of a Researcher - KOBYASHI Yukihiro

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KOBYASHI Yukihiro

Job title: Assistant Professor

Department: Department of Food Science and Technology

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Reduction in IgE reactivity of fish parvalbumin through heat denaturation

Yukihiro Kobayashi, Hiroyuki Kubota, Kenta Ishikawa, Risa Kawashima, Naoko Hamada-Sato , 2026.09

Fisheries Science

DOI
Identification of conformational IgE-binding epitopes of Pacific mackerel (Scomber japonicus) parvalbumin.

Yukihiro Kobayashi, Yuta Tanaka, Aika Morii, Kazuo Shiomi , 2026.09

Food chemistry

DOI
Reduction in IgE reactivity of fish parvalbumin through heat denaturation

Yukihiro Kobayashi, Hiroyuki Kubota, Kenta Ishikawa, Risa Kawashima, Naoko Hamada-Sato , 2026.09

Fisheries Science
Inhibition of the Maillard reaction by ohmic heating in a glucose–lysine model system

Yukihiro Kobayashi, Yuta Koguma, Naoko Sato‐Hamada , 2026.07

Journal of the Science of Food and Agriculture

DOI
Basophil activation to β′-component in adult-onset, salmon roe–induced anaphylaxis

Tsukasa Ugajin, Yukihiro Kobayashi, Karin Endo, Yutaka Shimizu, Hiroki Saeki, Naoko Okiyama , 2026.04

Journal of Allergy and Clinical Immunology: Global

DOI

魚類アレルゲン（パルブアルブミン）の耐熱性に関わる因子の解明

Project Period (FY)： 2023/04 - 2028/03 Investigator(s): 小林征洋

Grant-in-Aid for Scientific Research(C) Principal Investigator 23K05392
Study of conformational IgE-binding epitopes of fish allergen, parvalbumin

Project Period (FY)： 2020/04 - 2023/03 Investigator(s): KOBAYASHI Yukihiro

Grant-in-Aid for Scientific Research(C) Principal Investigator 20K06236

We analyzed the IgE-binding sites (epitopes) of parvalbumin (PV), a major allergen in teleost fish. Teleost fish have multiple homologous genes of PV (pvalb), but only pvalb1 to pavalb4 are highly expressed in muscle, and all allergenic PVs belong to these 4 genes. These homologous genes were likely generated by gene duplication after other vertebrates diverged from teleost fish. In addition, these genes were not found in non-allergen PVs of teleost fish or PVs of other organisms. The epitope and co-located residues were conserved in pvalb1 to pavalb4 of teleost fish, and were, however, frequently mutated in other organisms. The electrostatic potentials of these residues on the molecular surface were similar among teleost fish, but differed frequently among the other organisms.
魚類主要アレルゲンパルブアルブミンのアレルギー反応性の低減化法に関する研究

Project Period (FY)： 2013/04 - 2016/03

Grant-in-Aid for Young Scientists(B) Principal Investigator 25750023