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Kabeya Naoki
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Research Interests 【 display / non-display 】
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Biosynthesis
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Nutritional requirements
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Polyunsaturated fatty acid
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Desaturase
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Invertebrates
Research Areas 【 display / non-display 】
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Life Science / Aquatic life science
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Life Science / Aquatic life science
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Life Science / Evolutionary biology / Gene duplication, functionalisation, phylogenetic analysis
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Life Science / Molecular biology / Enzymatic function, Biosynthesis, Transgenic, Knockout
Papers 【 display / non-display 】
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Enzymatic basis underlying the biosynthesis of Δ7-desaturated C22 polymethylene-interrupted fatty acids across marine invertebrates.
Yingying Peng, Ai Iinuma, Yo Nakano, Michihiro Suezawa, Yutaka Haga, Naoki Kabeya , 2026.04
Biochimica et biophysica acta. Molecular and cell biology of lipids
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Methyl-end desaturases determine the capability for de novo biosynthesis of polyunsaturated fatty acids in bivalves.
Naoki Kabeya, Marc Ramos-Llorens, Yo Nakano, André Gomes-Dos-Santos, Amílcar Teixeira, Megumu Fujibayashi, Juan G Haro, Juan C Navarro, L Filipe C Castro, Yutaka Haga, Óscar Monroig , 2025.04
Biochimica et biophysica acta. Molecular and cell biology of lipids
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Enzymes enabling the biosynthesis of various C20 polyunsaturated fatty acids in a sea urchin Hemicentrotus pulcherrimus.
Yingying Peng, Yutaka Haga, Naoki Kabeya , 2025.01
Open biology
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A complete biosynthetic pathway of the long-chain polyunsaturated fatty acids in an amphidromous fish, ayu sweetfish Plecoglossus altivelis (Stomiati; Osmeriformes).
Bo Zhao, Yingying Peng, Yuki Itakura, Myriam Lizanda, Yutaka Haga, Shuichi Satoh, Juan C Navarro, Óscar Monroig, Naoki Kabeya , 2024.05
Biochimica et biophysica acta. Molecular and cell biology of lipids
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Fatty acid contents and its compositions of mesozooplankton community in the Kuroshio Current and neighboring waters
Toru Kobari, Nao Kominato, Reo Ishimaru, Masafumi Kodama, Gen Kume, Masaharu Hanai, Asuka Nitta, Naoki Kabeya , 2026.01
Progress in Oceanography
Books 【 display / non-display 】
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水産遺伝育種学
壁谷 尚樹 , 2017.03
東北大学出版会 , 第12章 遺伝子・細胞操作と水産育種における応用 , 0-0
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Research and Development in Aquaculture Nutrition
Naoki Kabeya , 2017
Universidad Autónoma de Nuevo León , Diversification of Fads2 in finfish species: Implications for aquaculture. , 0-0
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Elucidation of EPA and DHA biosynthetic capacity of marine copepods in the ecosystem
Project Period (FY): 2022/04 - 2025/03 Investigator(s): 壁谷尚樹
Grant-in-Aid for Scientific Research(B) Principal Investigator 23K23698
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Project Period (FY): 2021 - 2024 Investigator(s): 壁谷尚樹
Strengthen international collaborative research(A) Principal Investigator 20KK0348
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Establishment of tasty fish strain using surrogate broodstock
Project Period (FY): 2020/04 - 2023/03 Investigator(s): Yoshizaki Goro
Grant-in-Aid for Scientific Research(A) Co-Investigator 20H00430
We tested the feasibility of breeding individuals with high total lipids using the marine fish, Nibe, as a model. First, the total lipids of wild individuals were analyzed, and at the same time, the gonads of these individuals were cryopreserved in liquid nitrogen. After identifying individuals with high and low total lipids, their germ cells were transplanted into infertile recipients. They were then allowed to mature and then subjected to mating experiments. The results showed that the next generation derived from the recipients, receiving germ cells of individuals with high total lipids showed significantly higher total lipids than the next generation derived from the germ cells of individuals with low total lipids. These results indicate that fish fat content is inherited, which has been conventionally thought to be greatly affected by diet.
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Studies on the development of non-fishmeal/non-fish oil feed for sustainable aquaculture
Project Period (FY): 2019/04 - 2023/03 Investigator(s): Satoh Shuichi
Grant-in-Aid for Scientific Research(B) Co-Investigator 19H03047
Basical research for development of non-fish meal/non-fish oil feed for marine fish was conducted to develop the sustainable aquafeed. Marine fish require EPA and/or DHA as essential fatty acids. Therefore, non-fish meal/non-fish oil feed for marine fish was developed by using the dried powder of Schizochitrium which is micro algae rich in DHA. Firstly, a feeding experiment was conducted by using the experimental diet formulated with Schizochitrim powder at the level of DHA requirement. After a feeding trial, identical result was obtained between fish meal/fish oil based diet and non-fish meal/non-fish oil diet with Schizochitrium. A similar kind of experiment was conducted with yellowtail, however, palatability of the diet was too weak to grow. Thefore feed stimulant supplementation improved the feeding activity and resulted a similar growth as fish oil diet.
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The role of copepods as primary producers of polyunsaturated fatty acids
Project Period (FY): 2019/04 - 2022/03 Investigator(s): Kabeya Naoki
Grant-in-Aid for Young Scientists Principal Investigator 19K15908
The biosynthetic capabilities of polyunsaturated fatty acids (PUFA) in copepods were elucidated in the present project. The copepods were tiny crustacean species mainly inhabiting in the aquatic environment. Some PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are physiologically essential nutrients for many animals, although most of EPA and DHA are originated from marine environment. Therefore, understanding PUFA production mechanism in the marine ecosystem is important. In the present project, we have confirmed that particular species within copepods possessed high biosynthetic capabilities of PUFA including EPA and DHA, and hence those species could be primary producers of PUFA in the marine ecosystem.
Lesson Subject 【 display / non-display 】
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Special Seminar in Aquatic Bioscience
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Research in Aquatic Bioscience